TAS1R2 Gene Summary [Human]
Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TAS1R2 |
| Official Name | taste 1 receptor member 2 [Source:HGNC Symbol;Acc:HGNC:14905] |
| Ensembl ID | ENSG00000179002 |
| Bio databases IDs | |
| Aliases | taste 1 receptor member 2 |
| Synonyms | Aldh4a1, GPR71, LOC690574, T1R2, taste 1 receptor member 2, taste receptor, type 1, member 2, TR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAS1R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Receptor family ligand binding region
- DNA binding domain
- ligand-binding domain
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- venus Flytrap domain
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the TAS1R2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- D-glucose
- acetosulfam
- saccharin
- aspartame
- cisplatin
- Neoculin
- neohesperidin dihydrochalcone
- sucralose
- Miraculin
- 3M-002
role in cell
- phosphorylation in
- quantity
- size
- adipogenesis
- cytokinesis in
- calcium response
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAS1R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- sensory perception of sweet taste
- detection of chemical stimulus involved in sensory perception of sweet taste
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sweet taste receptor activity
- G-protein coupled receptor activity
- taste receptor activity