KCNAB3 Gene Summary [Human]
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | KCNAB3 |
| Official Name | potassium voltage-gated channel subfamily A regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6230] |
| Ensembl ID | ENSG00000170049 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily A regulatory beta subunit 3 |
| Synonyms | AKR6A9, C330022D06Rik, KCNA3.1B, KCNA3B, Kcnab4, KV-BETA-3, KV-β-3, mKv(beta)4, mKv(β)4, potassium voltage-gated channel, shaker-related subfamily, beta member 3, potassium voltage-gated channel, shaker-related subfamily, β member 3, potassium voltage-gated channel subfamily A regulatory beta subunit 3, potassium voltage-gated channel subfamily A regulatory β subunit 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNAB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldo-keto reductase (AKR) superfamily
- Aldo/keto reductase family
- potassium channel regulator
- protein binding
- voltage-dependent potassium channel beta subunit, animal
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- ulcerative colitis
- cutaneous B-cell lymphoma
- B-cell non-Hodgkin disease
- skin cancer
- mature B-cell neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Crohn disease
- insulin-dependent diabetes mellitus
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNAB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- voltage-gated potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- aldo-keto reductase (NADP) activity
- ion channel binding
- potassium channel regulator activity