Kcnab3 Gene Summary [Mouse]
Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Is expressed in central nervous system; eye; heart; intestine; and male reproductive gland or organ. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnab3 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, beta member 3 [Source:MGI Symbol;Acc:MGI:1336208] |
| Ensembl ID | ENSMUSG00000018470 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, beta member 3 |
| Synonyms | AKR6A9, C330022D06Rik, KCNA3.1B, KCNA3B, Kcnab4, KV-BETA-3, KV-β-3, mKv(beta)4, mKv(β)4, potassium voltage-gated channel, shaker-related subfamily, beta member 3, potassium voltage-gated channel, shaker-related subfamily, β member 3, potassium voltage-gated channel subfamily A regulatory beta subunit 3, potassium voltage-gated channel subfamily A regulatory β subunit 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnab3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldo-keto reductase (AKR) superfamily
- Aldo/keto reductase family
- potassium channel regulator
- protein binding
- voltage-dependent potassium channel beta subunit, animal
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- ulcerative colitis
- cutaneous B-cell lymphoma
- B-cell non-Hodgkin disease
- skin cancer
- mature B-cell neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Crohn disease
- insulin-dependent diabetes mellitus
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnab3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- voltage-gated potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- aldo-keto reductase (NADP) activity
- ion channel binding
- potassium channel regulator activity