NUDT9 Gene Summary [Human]
The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | NUDT9 |
| Official Name | nudix hydrolase 9 [Source:HGNC Symbol;Acc:HGNC:8056] |
| Ensembl ID | ENSG00000170502 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 9 |
| Synonyms | 1190002C07Rik, ADPR-PPase, nudix hydrolase 9, NUDT10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDT9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- phosphatase
- protein binding
- ADPribose diphosphatase
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDT9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ADP catabolic process
- nucleobase-containing small molecule metabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular vesicular exosome
- nuclear body
- mitochondrial matrix
- mitochondrion
- cell junction
Molecular Function
What the gene product does at the molecular level
- protein binding
- ADP-ribose diphosphatase activity
- ADP-sugar diphosphatase activity