TRIM11 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM11 |
| Official Name | tripartite motif containing 11 [Source:HGNC Symbol;Acc:HGNC:16281] |
| Ensembl ID | ENSG00000154370 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 11 |
| Synonyms | BIA1, RNF92, tripartite motif-containing 11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- protein binding activity, bridging
- transcription factor binding
- coiled-coil domain
- protein domain specific binding
- enzyme
- Ring finger domain
- protein binding
- B30.2 domain
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- polyglandular autoimmune syndrome type 1
- progressive supranuclear palsy
role in cell
- proliferation
- degradation in
- migration
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- negative regulation of viral entry into host cell
- innate immune response
- regulation of gene expression
- positive regulation of viral entry into host cell
- negative regulation of neurogenesis
- protein autoubiquitination
- protein ubiquitination
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein domain specific binding
- protein binding
- protein binding, bridging