STK17A Gene Summary [Human]
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | STK17A |
| Official Name | serine/threonine kinase 17a [Source:HGNC Symbol;Acc:HGNC:11395] |
| Ensembl ID | ENSG00000164543 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 17a, death-associated protein kinase-related 1 |
| Synonyms | DRAK1, serine/threonine kinase 17a |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK17A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- non-Hodgkin lymphoma
- non-Hodgkin disease
- irritable bowel syndrome
role in cell
- upregulation in
- apoptosis
- cytostasis
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK17A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of fibroblast apoptotic process
- regulation of reactive oxygen species metabolic process
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity