CD5 Gene Summary [Human]
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | CD5 |
| Official Name | CD5 molecule [Source:HGNC Symbol;Acc:HGNC:1685] |
| Ensembl ID | ENSG00000110448 |
| Bio databases IDs | |
| Aliases | CD5 molecule |
| Synonyms | CD5 ANTIGEN, CD5 molecule, LEU1, LOC100911215, Ly-1, Ly-12, Ly-A, Lyt-1, OKT1, T1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- extracellular domain
- cytoplasmic domain
- ectodomain
- transmembrane domain
- signal peptide
- protein binding
- cytosolic tail domain
- transmembrane receptor
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Waldenström macroglobulinemia
- liver cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- T-cell prolymphocytic leukemia
- hypothyroidism
- polyglandular autoimmune syndrome type 1
- hairy cell leukemia
role in cell
- apoptosis
- phosphorylation in
- binding in
- expression in
- production in
- quantity
- activation in
- proliferation
- number
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- immunological synapses
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- apoptotic signaling pathway
- cell recognition
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity