GPR34 Gene Summary [Human]
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
Details
| Type | Protein Coding |
| Official Symbol | GPR34 |
| Official Name | G protein-coupled receptor 34 [Source:HGNC Symbol;Acc:HGNC:4490] |
| Ensembl ID | ENSG00000171659 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 34 |
| Synonyms | G protein-coupled receptor 34, LPS1, LYPSR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR34 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- delayed hypersensitive reaction
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- heart disease
- metastasis
- infection by fungus
role in cell
- phosphorylation in
- apoptosis
- activation in
- proliferation
- production in
- abnormal morphology
- migration
- necrosis
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled purinergic nucleotide receptor activity