TNFRSF10D Gene Summary [Human]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF10D |
| Official Name | TNF receptor superfamily member 10d [Source:HGNC Symbol;Acc:HGNC:11907] |
| Ensembl ID | ENSG00000173530 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 10d |
| Synonyms | CD264, DCR2, TNF receptor superfamily member 10d, TRAIL-R4, TRAIL receptor 4, TRUNDD |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF10D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- ligand-binding domain
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
- pre-ligand assembly domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the TNFRSF10D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- asthma
- spondylarthritis
- ulcerative colitis
- rheumatoid arthritis
- intrauterine growth retardation
role in cell
- survival
- apoptosis
- activation in
- cell death
- phosphorylation in
- cell viability
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF10D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- TRAIL binding