KNDC1 Gene Summary [Human]
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | KNDC1 |
| Official Name | kinase non-catalytic C-lobe domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29374] |
| Ensembl ID | ENSG00000171798 |
| Bio databases IDs | |
| Aliases | kinase non-catalytic C-lobe domain containing 1 |
| Synonyms | 2410012C07RIK, B830014K08Rik, bB439H18.3, C10orf23, KIAA1768, kinase non-catalytic C-lobe domain containing 1, kinase non-catalytic C-lobe domain (KIND) containing 1, RASGEF2, RGD1565261, Very-KIND, VKIND |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KNDC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase noncatalytic C-lobe domain
- Protein Kinases, catalytic domain
- guanyl-nucleotide exchange factor
- protein binding
- REM
- Kinase non-catalytic C-lobe domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KNDC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendrite development
- cerebellar granule cell differentiation
- small GTPase mediated signal transduction
- positive regulation of protein phosphorylation
- regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- guanyl-nucleotide exchange factor complex
- neuronal cell body
- perikaryon
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity