MAP2 Gene Summary [Human]
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | MAP2 |
| Official Name | microtubule associated protein 2 [Source:HGNC Symbol;Acc:HGNC:6839] |
| Ensembl ID | ENSG00000078018 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 2 |
| Synonyms | Autoantigen M2, G1-397-34, M2, M2 mitochondrial autoantigen, MAP2R, microtubule-associated protein 2, MTAP2, repro4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PXXP Class I motif
- microtubule binding domain
- Tau and MAP protein, tubulin-binding repeat
- inter-repeat domain
- protein kinase binding
- MAP2/Tau projection domain
- SH2-domain binding
- R2 binding domain
- protein binding
- cytoskeletal regulatory protein binding
- proline rich domain
- projection domain
- microtubule binding
- actin binding
- tau-like microtubule binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cervical cancer
- prostate cancer
- dementia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- prostatic neoplasm
- Huntington disease
- anxiety disorder
role in cell
- migration
- transformation
- development
- formation
- binding
- organization
- assembly
- attachment
- extension
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- dendrite tip
- basal dendrites
- glutaminergic synapse
- microtubule cytoskeleton
- axon component
- Cytoplasm
- cilia
- cell surface
- intracellular space
- somatodendritic region
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- ribosome
- Nucleus
- Golgi Apparatus
- microtubules
- microtubule bundles
- cytosol
- membrane ruffles
- axon hillock
- growth cone
- neurites
- dendrite initial segments
- synapse
- neuritic shafts
- membrane processes
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- dendritic branches
- apical processes
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- negative regulation of axon extension
- regulation of protein localization
- regulation of microtubule polymerization
- central nervous system neuron development
- microtubule cytoskeleton organization
- dendrite development
- dendrite morphogenesis
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- neuronal cell body
- main axon
- axon hillock
- neuron projection
- microtubule associated complex
- microtubule
- dendrite
- dendritic growth cone
- initial segment
- cytoplasm
- dendritic shaft
- dendrite cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- tau protein binding
- structural molecule activity
- dystroglycan binding
- microtubule binding