Kndc1 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cerebellar granule cell differentiation; positive regulation of protein phosphorylation; and regulation of dendrite morphogenesis. Located in dendrite and neuronal cell body. Part of guanyl-nucleotide exchange factor complex. Is expressed in lung; nervous system; neural retina; ovary; and thymus. Orthologous to human KNDC1 (kinase non-catalytic C-lobe domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kndc1 |
| Official Name | kinase non-catalytic C-lobe domain (KIND) containing 1 [Source:MGI Symbol;Acc:MGI:1923734] |
| Ensembl ID | ENSMUSG00000066129 |
| Bio databases IDs | |
| Aliases | kinase non-catalytic C-lobe domain (KIND) containing 1 |
| Synonyms | 2410012C07RIK, B830014K08Rik, bB439H18.3, C10orf23, KIAA1768, kinase non-catalytic C-lobe domain containing 1, kinase non-catalytic C-lobe domain (KIND) containing 1, RASGEF2, RGD1565261, Very-KIND, VKIND |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kndc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase noncatalytic C-lobe domain
- Protein Kinases, catalytic domain
- guanyl-nucleotide exchange factor
- protein binding
- REM
- Kinase non-catalytic C-lobe domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kndc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendrite development
- cerebellar granule cell differentiation
- small GTPase mediated signal transduction
- positive regulation of protein phosphorylation
- regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- guanyl-nucleotide exchange factor complex
- neuronal cell body
- perikaryon
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity