PSMD7 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PSMD7 |
| Official Name | proteasome 26S subunit, non-ATPase 7 [Source:HGNC Symbol;Acc:HGNC:9565] |
| Ensembl ID | ENSG00000103035 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 7, Mov34 homolog |
| Synonyms | MOV34, MOV34L, P40, Proteasome 25s subunit, non-atpase, 7 (moloney leukaemia virus-34 proviral integration homolog), proteasome 26S subunit, non-ATPase 7, proteasome (prosome, macropain) 26S subunit, non-ATPase, 7, Proteasome subunit 26s non-atpase 7, Rpn8, S12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mpr1p, Pad1p N-terminal (MPN) domains
- protein homodimerization
- protein binding
- Maintenance of mitochondrial structure and function
Pathways
Biological processes and signaling networks where the PSMD7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- gastric cancer
role in cell
- expression in
- activation in
- migration
- phosphorylation in
- proliferation
- degradation in
- apoptosis
- cell death
- invasion by
- CSN5i-3 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle
- membrane
- cytosol
- proteasome complex
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- peptidase activity