HINFP Gene Summary [Human]
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | HINFP |
| Official Name | histone H4 transcription factor [Source:HGNC Symbol;Acc:HGNC:17850] |
| Ensembl ID | ENSG00000172273 |
| Bio databases IDs | |
| Aliases | histone H4 transcription factor, histone nuclear factor P |
| Synonyms | histone H4 transcription factor, MIZF, RGD1311492, ZNF743 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HINFP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- histone binding
- transcription regulator
- nucleic acid binding
- enzyme binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- zinc finger domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
regulated by
- tetradecanoylphorbol acetate
- garcinol
- amiloride
role in cell
- expression in
- proliferation
- differentiation
- S phase
- invasion by
- DNA damage response
- G1/S phase transition
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HINFP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- transcription, DNA-dependent
- anatomical structure development
- myoblast differentiation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- establishment of protein localization
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage checkpoint
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of gene expression
- G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cajal body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- histone binding
- enzyme binding