GSPT1 Gene Summary [Human]
Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GSPT1 |
| Official Name | G1 to S phase transition 1 [Source:HGNC Symbol;Acc:HGNC:4621] |
| Ensembl ID | ENSG00000103342 |
| Bio databases IDs | |
| Aliases | G1 to S phase transition 1, eukaryotic release factor 3a |
| Synonyms | 551G9.2, AI314175, eRF3a, ETF3A, G1st, G1 to S phase transition 1, GST1, Gst-1-hs, Guanine nucleotide regulatory protein 1, LOC100911685 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSPT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Elongation factor Tu C-terminal domain
- GTPase
- protein binding
- translation release factor
- Elongation factor Tu domain 2
- translation regulator
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- sulfate adenylyltransferase, large subunit
- small GTP-binding protein domain
- Ataxin-2 C-terminal region
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- papillary thyroid carcinoma
- papillary thyroid cancer
- renal cell carcinoma
- renal cell cancer
- ductal breast carcinoma
- ductal breast cancer
- lung cancer
role in cell
- proliferation
- cell cycle progression
- G1 phase
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSPT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational termination
- regulation of translational termination
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- G1/S transition of mitotic cell cycle
- protein methylation
- translation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- cytosol
- translation release factor complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- protein binding
- translation release factor activity
- GTPase activity