H1-0 Gene Summary [Human]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | H1-0 |
| Official Name | H1.0 linker histone [Source:HGNC Symbol;Acc:HGNC:4714] |
| Ensembl ID | ENSG00000189060 |
| Bio databases IDs | |
| Aliases | H1.0 linker histone, H1.0, H1(0), H1-0 |
| Synonyms | D130017D06Rik, H1.0, H1.0 linker histone, H1F0, H1FV, Histone h1, Histone H1o/H5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human H1-0 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- linker histone H1 and H5 family
- binding protein
- H15
- globular domain
- double-stranded DNA binding
- nuclear localization sequence
- chromatin binding
- protein binding
- DNA binding
- AT DNA binding
Pathways
Biological processes and signaling networks where the H1-0 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- actin cytoskeleton
- cell cortex
- Golgi Apparatus
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human H1-0 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription regulatory region DNA binding
- heterochromatin assembly
- chromosome condensation
- nucleosome assembly
- negative regulation of DNA recombination
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- nuclear body
- transcriptional repressor complex
- actin cytoskeleton
- Golgi apparatus
- nucleosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- structural constituent of chromatin
- protein binding
- RNA binding
- nucleosome binding
- nucleosomal DNA binding
- double-stranded DNA binding
- AT DNA binding