CKS2 Gene Summary [Human]
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CKS2 |
| Official Name | CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000] |
| Ensembl ID | ENSG00000123975 |
| Bio databases IDs | |
| Aliases | CDC28 protein kinase regulatory subunit 2 |
| Synonyms | 1110038L14Rik, CDC28 protein KINASE REGULATORY subunit 2, CDC28 REGULATORY subunit 2, CKSHS2, P13SUC1, RGD1562047 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CKS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- chromatin binding
- protein binding
- Cyclin-dependent kinase regulatory subunit
Pathways
Biological processes and signaling networks where the CKS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- papillary thyroid carcinoma
- epithelial cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
- organismal death
- HER2 negative hormone receptor negative breast cancer
- diffuse cutaneous systemic sclerosis
role in cell
- growth
- migration
- proliferation
- invasion by
- expression in
- apoptosis
- cell viability
- number
- colony formation
- S phase checkpoint control
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CKS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- fibroblast proliferation
- regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- meiosis I
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- histone binding
- chromatin binding