XAGE3 Gene Summary [Human]
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | XAGE3 |
| Official Name | X antigen family member 3 [Source:HGNC Symbol;Acc:HGNC:14618] |
| Ensembl ID | ENSG00000171402 |
| Bio databases IDs | |
| Aliases | X antigen family member 3, cancer/testis antigen family 12, member 3a, cancer/testis antigen family 12, member 3b |
| Synonyms | CT12.3a, CT12.3b, GAGED4, PLAC6, pp9012, X antigen family member 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XAGE3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAGE protein
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XAGE3 gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- protein binding