TRIB1 Gene Summary [Human]
Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRIB1 |
| Official Name | tribbles pseudokinase 1 [Source:HGNC Symbol;Acc:HGNC:16891] |
| Ensembl ID | ENSG00000173334 |
| Bio databases IDs | |
| Aliases | tribbles pseudokinase 1 |
| Synonyms | A530090O15Rik, C8FW, GIG-2, HTRB-1, PRMP, SKIP1, TRB-1, tribbles pseudokinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ubiquitin protein ligase binding
- protein kinase binding
- Protein Kinases, catalytic domain
- protein kinase inhibitor activity
- kinase-like domain
- transcription factor binding
- protein binding
- enzyme regulator activity
- Protein kinase domain
- protein-tyrosine kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- acute myeloid leukemia
- epileptic seizure
- lipodystrophy
- insulin resistance
- transient myeloproliferative disorder of Down syndrome
- growth failure
- metabolic syndrome X
- rotator cuff injury
role in cell
- expression in
- number
- degradation in
- acetylation in
- growth
- migration
- phosphorylation in
- accumulation in
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAP kinase activity
- JNK cascade
- negative regulation of sequence-specific DNA binding transcription factor activity
- protein phosphorylation
- negative regulation of neutrophil differentiation
- negative regulation of protein kinase activity
- positive regulation of eosinophil differentiation
- positive regulation of macrophage differentiation
- negative regulation of smooth muscle cell proliferation
- negative regulation of smooth muscle cell migration
- response to lipopolysaccharide
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin protein ligase binding
- protein binding
- protein kinase activity
- ubiquitin-protein ligase regulator activity
- protein kinase inhibitor activity
- mitogen-activated protein kinase kinase binding