OLR1
OLR1 Gene Summary
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | OLR1 |
| Official Name | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] |
| Ensembl ID | ENSG00000173391 |
| Bio databases IDs | |
| Aliases | oxidized low density lipoprotein receptor 1 |
| Synonyms | CLEC8A,LOX-1,Oldlr1,Oldr1,oxidized low density lipoprotein (lectin-like) receptor 1,oxidized low density lipoprotein receptor 1,SCARE1,SLOX1,SR-EI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Ezrin/radixin/moesin, alpha-helical domain
- Growth-arrest specific micro-tubule binding
- Lectin C-type domain
- Ly49-like protein, N-terminal region
- low-density lipoprotein receptor
- protein binding
- identical protein binding
- Apolipoprotein A1/A4/E domain
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RXRA
- EP300
- HSP70
- TCP1
- SYVN1
- RHOB
- EZH2
- PPARGC1A
- NCOA1
- RHOC
disease
- hypertension
- neoplasia
- edema
- orthostatic hypotension
- colon cancer
- liver cancer
- chronic periodontal disease
- tumorigenesis
- acute myeloid leukemia
- atherosclerosis
regulated by
- N-acetyl-L-cysteine
- NFE2L2
- LDL
- fluticasone propionate
- APOE
- tetradecanoylphorbol acetate
- aspirin
- TGFB1
- tripterine
- lipopolysaccharide
regulates
- VEGF
- TNF
- NFkB (complex)
- CCL2
- CXCL8
- CCN2
- ERK1/2
- NFKBIA
- reactive oxygen species
- IL6
role in cell
- cell viability
- phosphorylation in
- production in
- survival
- apoptosis
- proliferation
- expression in
- number
- recruitment
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- cellular membrane
- tertiary granule membrane
- specific granule membrane
- nucleoplasm
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the OLR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- vesicle-mediated transport
- proteolysis
- blood circulation
- lipoprotein metabolic process
- leukocyte cell-cell adhesion
- immune system process
CELLULAR COMPONENT
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- membrane raft
- receptor complex
- extracellular region
- plasma membrane
- tertiary granule membrane
- nucleoplasm
- specific granule membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- low-density lipoprotein receptor activity
- carbohydrate binding