FKBP2 Gene Summary [Human]
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Details
| Type | Retained Intron |
| Official Symbol | FKBP2 |
| Official Name | FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HGNC:3718] |
| Ensembl ID | ENSG00000173486 |
| Bio databases IDs | |
| Aliases | FKBP prolyl isomerase 2, FK506 binding protein 2 (13kD), peptidyl-prolyl cis-trans isomerase, rapamycin-binding protein, proline isomerase |
| Synonyms | FK506 binding protein 2, FKBP-13, FKBP prolyl isomerase 2, mFKBP13, mFKBP2, PPIase, RGD1560660 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FKBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- FK506 binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FKBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- FK506 binding