ANGPT2 Gene Summary [Human]
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | ANGPT2 |
| Official Name | angiopoietin 2 [Source:HGNC Symbol;Acc:HGNC:485] |
| Ensembl ID | ENSG00000091879 |
| Bio databases IDs | |
| Aliases | angiopoietin 2 |
| Synonyms | AGPT2, ANG2, ANG II, angiopoietin 2, Angiotensin 2, Angiotensin II, Angp2, Angrp, LMPHM10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGPT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- receptor antagonist activity
- fibrinogen-like domain
- coiled-coil domain
- receptor agonist activity
- protein binding
- receptor binding
- vascular endothelial growth factor receptor binding
- FReD
- growth factor
Pathways
Biological processes and signaling networks where the ANGPT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hypertension
- neoplasia
- metastasis
- glioblastoma
- cardiomyopathy
- abscess
- exudative age-related macular degeneration
- organismal death
- diabetic macular edema
role in cell
- dephosphorylation in
- expression in
- proliferation
- accumulation in
- activation
- differentiation
- phosphorylation in
- binding
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGPT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- maternal process involved in female pregnancy
- negative regulation of positive chemotaxis
- signal transduction
- response to organic cyclic compound
- positive regulation of angiogenesis
- response to mechanical stimulus
- response to glucose stimulus
- response to hypoxia
- negative regulation of cell-substrate adhesion
- angiogenesis
- Tie receptor signaling pathway
- cellular response to growth factor stimulus
- glomerulus vasculature development
- gene expression
- organ regeneration
- response to activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- receptor binding
- receptor tyrosine kinase binding