PTGES3 Gene Summary [Human]
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
Details
| Type | Processed Transcript |
| Official Symbol | PTGES3 |
| Official Name | prostaglandin E synthase 3 [Source:HGNC Symbol;Acc:HGNC:16049] |
| Ensembl ID | ENSG00000110958 |
| Bio databases IDs | |
| Aliases | prostaglandin E synthase 3 |
| Synonyms | 5730442A20Rik, cPGES, p23, p23 COCHAPERONE, p23 PR RELATED, PGES3, prostaglandin E synthase 3, Ptges, RGD1561913, sid3177, TEBP, Telomerase Binding Protein p23, Zhf6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGES3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- alpha-crystallin Hsps/p23-like
- heat shock protein binding
- enzyme binding
- enzyme
- p53 binding
- protein binding
- telomerase
- prostaglandin-E synthase
Pathways
Biological processes and signaling networks where the PTGES3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- Alzheimer disease
- COVID-19
- Parkinson disease
- atelectasis
- dyspnea
- aortic valve calcification
role in cell
- proliferation
- apoptosis
- expression in
- invasion
- maintenance
- interference in
- augmentation in
- adhesion
- aggregation in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- actin filaments
- cytosol
- nucleoplasm
- telomeres
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGES3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucocorticoid receptor signaling pathway
- positive regulation of phosphorylation
- lung saccule development
- signal transduction
- telomere maintenance via telomerase
- telomere maintenance
- chaperone mediated protein folding requiring cofactor
- protein folding
- skin development
- fibroblast proliferation
- positive regulation of telomerase activity
- cyclooxygenase pathway
- glycogen biosynthetic process
- prostaglandin biosynthetic process
- chaperone-mediated protein complex assembly
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- cytosol
- macromolecular complex
- telomerase holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- telomerase activity
- DNA polymerase binding
- protein binding
- prostaglandin-E synthase activity
- chaperone binding
- Hsp90 protein binding
- unfolded protein binding