SULT1B1 Gene Summary [Human]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SULT1B1 |
| Official Name | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] |
| Ensembl ID | ENSG00000173597 |
| Bio databases IDs | |
| Aliases | sulfotransferase family 1B member 1 |
| Synonyms | LOC64305, ST1B1, ST1B2, St1b3, St2b2, sulfotransferase family 1B member 1, sulfotransferase family 1B, member 1, sulphotransferase family 1B member 1, sulphotransferase family 1B, member 1, SULT1B2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SULT1B1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- Sulfotransferase domain
- enzyme
- protein binding
- aryl sulfotransferase
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the SULT1B1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- primary pulmonary hypertension
- nicotine dependence
- high-grade serous ovarian cancer
regulates
- thyroid hormone
- ethanol
- 8-hydroxy-6-formylindolo[3,2-b]carbazole
- xenobiotic
- phenol derivative
- flavonoid
- 2-hydroxy-6-formylindolo[3,2-b]carbazole
- raloxifene
- phosphoadenosine phosphosulfate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SULT1B1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- phenol-containing compound metabolic process
- xenobiotic metabolic process
- ethanol catabolic process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- sulfation
- flavonoid metabolic process
- cellular biogenic amine metabolic process
- thyroid hormone metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- aryl sulfotransferase activity
- sulfotransferase activity