TARS1 Gene Summary [Human]
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TARS1 |
| Official Name | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] |
| Ensembl ID | ENSG00000113407 |
| Bio databases IDs | |
| Aliases | threonyl-tRNA synthetase 1, threonine tRNA ligase 1, cytoplasmic |
| Synonyms | D15Wsu59e, PL-7, TARS, threonyl-tRNA synthetase 1, ThrRS, TRAS, TTD7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TARS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HGTP_anticodon
- threonyl-tRNA synthetase
- TGS domain
- class_II_aaRS-like_core
- ATP binding
- enzyme
- protein binding
- identical protein binding
- threonine-tRNA ligase
- tRNA synthetase class II core domain (G, H, P, S and T)
- Anticodon binding domain
- zinc ion binding
- Ubl1_cv_Nsp3_N-like
- Threonyl and Alanyl tRNA synthetase second additional domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TARS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- threonyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- identical protein binding
- protein binding
- threonine-tRNA ligase activity
- tRNA binding