GPRC6A
GPRC6A Gene Summary
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | GPRC6A |
| Official Name | G protein-coupled receptor class C group 6 member A [Source:HGNC Symbol;Acc:HGNC:18510] |
| Ensembl ID | ENSG00000173612 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor class C group 6 member A |
| Synonyms | bA86F4.3,GPCR,G protein-coupled receptor class C group 6 member A,G protein-coupled receptor, class C, group 6, member A,G protein-coupled receptor, family C, group 6, member A |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- Receptor family ligand binding region
- Type 1 periplasmic binding fold superfamily
- Nine Cysteines Domain of family 3 GPCR
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPRC6A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GPRC6A
- IGF1R
disease
- impaired glucose tolerance
- hyperglycemia
- prostate cancer
- hypercalciuria
- diabetic nephropathy
- hepatic steatosis
- low molecular weight proteinuria
- feminization
- hyperphagia
- bradycardia
regulated by
- Ca2+
- Pertussis toxin
- GNAQ
- heavy metal
- vitamin D
- Gd3+
- RGS4
- magnesium
- testosterone
- aluminum
regulates
- Ca2+
- GCG
- LIPE
- cyclic AMP
- PLIN1
- TNF
- D-glucose
- testosterone
- Ins1
- PNPLA2
role in cell
- phosphorylation in
- size
- generation in
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Nucleus
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GPRC6A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- response to amino acid stimulus
- regulation of testosterone biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity