Gprc6a Gene Summary [Mouse]
Enables G protein-coupled peptide receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of testosterone biosynthetic process. Is active in plasma membrane. Is expressed in several structures, including femur; liver; male reproductive gland or organ; musculature; and spleen. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gprc6a |
| Official Name | G protein-coupled receptor, family C, group 6, member A [Source:MGI Symbol;Acc:MGI:2429498] |
| Ensembl ID | ENSMUSG00000019905 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor, family C, group 6, member A |
| Synonyms | bA86F4.3, GPCR, G protein-coupled receptor class C group 6 member A, G protein-coupled receptor, class C, group 6, member A, G protein-coupled receptor, family C, group 6, member A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gprc6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- Receptor family ligand binding region
- Type 1 periplasmic binding fold superfamily
- Nine Cysteines Domain of family 3 GPCR
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gprc6a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- hyperglycemia
- prostate cancer
- hypercalciuria
- diabetic nephropathy
- hepatic steatosis
- low molecular weight proteinuria
- feminization
- hyperphagia
- bradycardia
role in cell
- phosphorylation in
- size
- generation in
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Nucleus
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gprc6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- response to amino acid stimulus
- regulation of testosterone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity