FBXO45 Gene Summary [Human]
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | FBXO45 |
| Official Name | F-box protein 45 [Source:HGNC Symbol;Acc:HGNC:29148] |
| Ensembl ID | ENSG00000174013 |
| Bio databases IDs | |
| Aliases | F-box protein 45 |
| Synonyms | 2610017J04RIK, F-box protein 45, Fbx45, LOC200933, RGD1311861 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- SPRY domain
- F-box-like
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- organismal death
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- lack of spontaneous movement
- kyphosis
- epithelial cancer
- hepatocellular carcinoma
- respiratory failure
role in cell
- apoptosis
- expression in
- proliferation
- formation in
- abnormal morphology
- migration
- formation
- invasion by
- signaling in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- presynaptic regions
- cytosol
- nucleoplasm
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly involved in innervation
- protein K48-linked ubiquitination
- corticospinal tract morphogenesis
- cerebral cortex radially oriented cell migration
- cerebral cortex tangential migration
- response to DNA damage stimulus
- anterior commissure morphogenesis
- ubiquitin-dependent protein catabolic process
- neuron migration
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of synaptic vesicle exocytosis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- nucleus
- postsynaptic membrane
- cytoplasm
- SCF ubiquitin ligase complex
- synapse
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding