IFNLR1 Gene Summary [Human]
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFNLR1 |
| Official Name | interferon lambda receptor 1 [Source:HGNC Symbol;Acc:HGNC:18584] |
| Ensembl ID | ENSG00000185436 |
| Bio databases IDs | |
| Aliases | interferon lambda receptor 1 |
| Synonyms | CRF2-12, CRF2/12, IFN LAMBDA R1, IFNLR, IFN λ R1, Il28r, IL-28R1, IL28RA, interferon lambda receptor 1, interferon, lambda receptor 1, interferon λ receptor 1, interferon, λ receptor 1, LICR2, RGD1562689 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNLR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- JAK1bd_box_IFNLR1-like
- cytokine receptor
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IFNLR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulosclerosis
- infection
- multiple sclerosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- psoriasis
- chronic hepatitis C
- infection by human herpesvirus 2
role in cell
- proliferation
- activation
- activation in
- expression in
- binding in
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNLR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to type III interferon
- cytokine-mediated signaling pathway
- negative regulation of cell proliferation
- regulation of defense response to virus by host
- defense response to virus
- mucosal immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- interleukin-28 receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine receptor activity