PRDX1 Gene Summary [Human]
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | PRDX1 |
| Official Name | peroxiredoxin 1 [Source:HGNC Symbol;Acc:HGNC:9352] |
| Ensembl ID | ENSG00000117450 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 1 |
| Synonyms | ENHANCER, Hbp23, MSP23, NKEF-A, OSF-3, PAG, PAGA, PAGB, PEROXIREDOXIN 1, PEROXYREDOXIN 1, PrdxI, PRX1, PRXI, TDPX2, TDX2, TPxA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRDX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxiredoxin
- peroxidase
- peroxidase (miscellaneous)
- C-terminal domain of 1-Cys peroxiredoxin
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- thioredoxin peroxidase
- AhpC/TSA family
- enzyme
- heme binding
- protein binding
- identical protein binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the PRDX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- non-small cell lung cancer
- breast cancer
- epithelial neoplasia
- abdominal cancer
- breast or ovarian cancer
- epithelial cancer
- urogenital cancer
- breast carcinoma
regulated by
- NADPH
- TNF
- methotrexate
- lipopolysaccharide
- N(G)-monomethyl-D-arginine
- forskolin
- SP600125
- carbon monoxide
- hydrogen peroxide
- cisplatin
role in cell
- apoptosis
- migration
- expression in
- cell death
- activation in
- number
- proliferation
- binding in
- quantity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- peroxisomal matrix
- cell surface
- pericentrosomal region
- cellular membrane
- Nucleus
- centrosome
- Endoplasmic Reticulum
- cytosol
- mitochondrial matrix
- nuclear foci
- chromatin
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRDX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- erythrocyte homeostasis
- cell redox homeostasis
- natural killer cell mediated cytotoxicity
- I-kappaB kinase/NF-kappaB cascade
- hydrogen peroxide catabolic process
- fibroblast proliferation
- response to oxidative stress
- skeletal system development
- leukocyte activation
- removal of superoxide radicals
- regulation of stress-activated MAPK cascade
- cellular response to stress
- natural killer cell activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- melanosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- identical protein binding
- protein binding
- RNA binding
- cadherin binding
- thioredoxin peroxidase activity