ODAPH Gene Summary [Human]
Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]
Details
| Type | Processed Transcript |
| Official Symbol | ODAPH |
| Official Name | odontogenesis associated phosphoprotein [Source:HGNC Symbol;Acc:HGNC:26300] |
| Ensembl ID | ENSG00000174792 |
| Bio databases IDs | |
| Aliases | odontogenesis associated phosphoprotein, amelogenesis imperfecta type IIA4 |
| Synonyms | AI2A4, C4orf26, Gm1045, Gm1045-a, Gm1045-b, odontogenesis associated phosphoprotein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ODAPH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Odontogenesis associated phosphoprotein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ODAPH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- positive regulation of biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding