TRPC4AP Gene Summary [Human]
Enables phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRPC4AP |
| Official Name | transient receptor potential cation channel subfamily C member 4 associated protein [Source:HGNC Symbol;Acc:HGNC:16181] |
| Ensembl ID | ENSG00000100991 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily C member 4 associated protein, protein phosphatase 1, regulatory subunit 158 |
| Synonyms | 4833429F06Rik, C20orf188, D2Ertd113e, mFLJ00177, PPP1R158, transient receptor potential cation channel subfamily C member 4 associated protein, transient receptor potential cation channel, subfamily C, member 4 associated protein, TRRP4AP, TRUSS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRPC4AP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel
- protein binding activity, bridging
- protein binding
- Protein of unknown function (DUF3689)
- transporter
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- melanoma cancer
- venous thromboembolism
- non-melanoma skin cancer
- melanoma
- portal hypertension
- androgenic alopecia
regulated by
- PELP1
- E1a
role in cell
- production in
- transformation
- transactivation in
- destruction in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRPC4AP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion transmembrane transport
- hair follicle maturation
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- Cul4A-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- calcium channel activity