SLC2A12 Gene Summary [Human]
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC2A12 |
| Official Name | solute carrier family 2 member 12 [Source:HGNC Symbol;Acc:HGNC:18067] |
| Ensembl ID | ENSG00000146411 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 12 |
| Synonyms | GLUT-12, GLUT8, solute carrier family 2 (facilitated glucose transporter), member 12, solute carrier family 2 member 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC2A12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- renal clear cell adenocarcinoma
- open-angle glaucoma
- renal clear cell cancer
- prostatic carcinoma
- prostate cancer
- coronary artery disease
- dilated cardiomyopathy
regulates
- D-glucose
- hexose
- uric acid
- SLC1A5
role in cell
- proliferation
- apoptosis
- activation
- glycolysis in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC2A12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circulatory system development
- hexose transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- D-glucose transmembrane transporter activity
- symporter activity
- glucose transmembrane transporter activity