CTDNEP1 Gene Summary [Human]
Enables protein serine/threonine phosphatase activity. Involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Part of Nem1-Spo7 phosphatase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CTDNEP1 |
| Official Name | CTD nuclear envelope phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:19085] |
| Ensembl ID | ENSG00000175826 |
| Bio databases IDs | |
| Aliases | CTD nuclear envelope phosphatase 1, C-terminal domain nuclear envelope phosphatase 1 |
| Synonyms | 2610507E10Rik, CTD nuclear envelope phosphatase 1, DULLARD, HSA011916, NET56 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTDNEP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FCP1-like phosphatase, phosphatase domain
- protein serine/threonine phosphatase
- protein phosphatase
- phosphatase
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- perinuclear space
- nuclear rim
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTDNEP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear envelope organization
- positive regulation of triglyceride biosynthetic process
- mitotic nuclear envelope disassembly
- protein dephosphorylation
- mesoderm development
- positive regulation of canonical Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- gamete generation
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- nuclear envelope
- nuclear membrane
- cytoplasm
- Nem1-Spo7 phosphatase complex
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- myosin phosphatase activity