DDX25 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DDX25 |
| Official Name | DEAD-box helicase 25 [Source:HGNC Symbol;Acc:HGNC:18698] |
| Ensembl ID | ENSG00000109832 |
| Bio databases IDs | |
| Aliases | DEAD-box helicase 25, gonadotropin-regulated testicular RNA helicase |
| Synonyms | DEAD-box helicase 25, DEAD-box protein 25, GRTH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- ATP binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- ATPase
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- Alzheimer disease
- bipolar disorder
- azoospermia
role in cell
- expression in
- apoptosis
- phosphorylation in
- development
- abnormal morphology
- elongation
- size
- molecular cleavage in
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- sister chromatids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- regulation of translation
- spermatid development
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- cytoplasmic stress granule
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA helicase activity
- mRNA binding