BNIP3
BNIP3 Gene Summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | BNIP3 |
| Official Name | BCL2 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1084] |
| Ensembl ID | ENSG00000176171 |
| Bio databases IDs | |
| Aliases | BCL2 interacting protein 3, nineteen kD interacting protein-3, Hypoxia-Activated BNIP3 Overlapping Non-coding RNA |
| Synonyms | BCL2/adenovirus E1B interacting protein 3,BCL2 interacting protein 3,HABON,NIP3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- conserved domain
- LC3-interacting region
- Bcl-2 homology 3 domain
- BNIP3
- transmembrane domain
- protein binding activity, bridging
- enzyme binding
- protein homodimerization
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the BNIP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- BCL2L1
- BCL2
- FBXL4
- BNIP3L
- MAP1LC3A
- KTN1
- TMEM101
- TMEM11
- BNIP3
- RNASEK
disease
- pancreatic epithelial cancer
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
- androgenic alopecia
- mucopolysaccharidosis type IVB
- Duchenne muscular dystrophy
- mucopolysaccharidosis, MPS-IV-A
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- rheumatoid arthritis
regulated by
- dexamethasone
- ACE2
- PRKCD
- PPARGC1A
- nitric oxide
- irinotecan
- heavy metal
- tretinoin
- KRAS
- 5-fluorouracil
regulates
- reactive oxygen species
- Ca2+
- BCL2
- cytochrome C
- lipid
- MTOR
- BCL2L1
- RHEB
- GABARAPL2
- BNIP3
role in cell
- cell viability
- expression in
- activation
- apoptosis
- proliferation
- cell death
- differentiation
- phosphorylation in
- generation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial outer membrane
- nucleoplasm
- nuclear envelope
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the BNIP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- response to hyperoxia
- positive regulation of programmed cell death
- positive regulation of protein complex disassembly
- response to axon injury
- negative regulation of programmed cell death
- brown fat cell differentiation
- response to hypoxia
- negative regulation of mitochondrial membrane potential
- negative regulation of mitochondrial fusion
- elevation of mitochondrial calcium ion concentration
- cardiac muscle cell apoptotic process
- autophagic cell death
- defense response to virus
- cellular response to cobalt ion
- cellular response to hypoxia
- cellular response to hydrogen peroxide
- neuron apoptotic process
- negative regulation of reactive oxygen species metabolic process
- positive regulation of macroautophagy
- mitochondrial protein catabolic process
- oligodendrocyte differentiation
- negative regulation of membrane potential
- positive regulation of release of cytochrome c from mitochondria
- mitochondrial fragmentation involved in apoptotic process
- cerebral cortex development
- positive regulation of mitochondrial fission
- regulation of mitochondrial membrane permeability
- mitochondrion degradation
- positive regulation of autophagy
- reactive oxygen species metabolic process
- response to bacterium
- cellular response to mechanical stimulus
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of cardiac muscle cell apoptotic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear envelope
- postsynaptic density
- nucleus
- dendrite
- mitochondrial membrane
- cytoplasm
- mitochondrion
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- GTPase binding