ATAD5 Gene Summary [Human]
Enables DNA clamp unloader activity. Involved in DNA clamp unloading; positive regulation of DNA replication; and positive regulation of cell cycle G2/M phase transition. Part of Elg1 RFC-like complex. Biomarker of neurilemmoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Non-Stop Decay |
| Official Symbol | ATAD5 |
| Official Name | ATPase family AAA domain containing 5 [Source:HGNC Symbol;Acc:HGNC:25752] |
| Ensembl ID | ENSG00000176208 |
| Bio databases IDs | |
| Aliases | ATPase family AAA domain containing 5, enhanced level of genomic instability 1 homolog (S. cerevisiae) |
| Synonyms | ATPase family AAA domain containing 5, ATPase family, AAA domain containing 5, C130052G03Rik, C17orf41, ELG1, FRAG1, Gm17, RGD1561464 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATAD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase family associated with various cellular activities (AAA)
- enzyme
- protein binding
- DNA dependent ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial ovarian cancer
- epithelial cancer
- cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
- lung squamous cell carcinoma
role in cell
- proliferation
- number
- crizotinib sensitivity
- synthesis in
- mono-ubiquitination in
- deubiquitination in
- class switching
- CSN5i-3 sensitivity
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATAD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA replication involved in S phase
- signal transduction in response to DNA damage
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of B cell proliferation
- positive regulation of DNA replication
- positive regulation of isotype switching to IgG isotypes
- isotype switching
Cellular Component
Where in the cell the gene product is active
- Elg1 RFC-like complex
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding