TBX21 Gene Summary [Human]
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TBX21 |
| Official Name | T-box transcription factor 21 [Source:HGNC Symbol;Acc:HGNC:11599] |
| Ensembl ID | ENSG00000073861 |
| Bio databases IDs | |
| Aliases | T-box transcription factor 21 |
| Synonyms | IMD88, T-BET, TBLYM, T-box 21, T-box transcription factor 21, TBT1, T-PET |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBX21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- Casein kinase i phosphorylation site
- nucleic acid binding
- transcription modulation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- T-box
- double-stranded DNA binding
- DNA-binding domain of the T-box transcription factor family
- T-box domain
Pathways
Biological processes and signaling networks where the TBX21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- chronic lymphocytic leukemia
- septic shock
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- immunodeficiency 88
- asthma
- acute myeloid leukemia
- atopic dermatitis
role in cell
- differentiation
- binding in
- quantity
- survival
- migration
- production in
- expression in
- repression in
- cell death
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- intracellular space
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBX21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of isotype switching to IgG isotypes
- T-helper 1 cell lineage commitment
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of T cell differentiation
- negative regulation of T-helper 17 cell lineage commitment
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of interleukin-2 production
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of T-helper 17 cell differentiation
- positive regulation of T-helper 1 cell cytokine production
- lymphocyte migration
- cell fate specification
- negative regulation of T-helper 2 cell cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- neuronal cell body
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity