Atad5 Gene Summary [Mouse]
Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and nuclear DNA replication. Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Located in nucleus. Is expressed in liver; metanephros; midbrain ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atad5 |
| Official Name | ATPase family, AAA domain containing 5 [Source:MGI Symbol;Acc:MGI:2442925] |
| Ensembl ID | ENSMUSG00000017550 |
| Bio databases IDs | |
| Aliases | ATPase family, AAA domain containing 5 |
| Synonyms | ATPase family AAA domain containing 5, ATPase family, AAA domain containing 5, C130052G03Rik, C17orf41, ELG1, FRAG1, Gm17, RGD1561464 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atad5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase family associated with various cellular activities (AAA)
- enzyme
- protein binding
- DNA dependent ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial ovarian cancer
- epithelial cancer
- cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
- lung squamous cell carcinoma
role in cell
- proliferation
- number
- crizotinib sensitivity
- synthesis in
- mono-ubiquitination in
- deubiquitination in
- class switching
- CSN5i-3 sensitivity
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atad5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA replication involved in S phase
- signal transduction in response to DNA damage
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of B cell proliferation
- positive regulation of DNA replication
- positive regulation of isotype switching to IgG isotypes
- isotype switching
Cellular Component
Where in the cell the gene product is active
- Elg1 RFC-like complex
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding