FOXC2 Gene Summary [Human]
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXC2 |
| Official Name | forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801] |
| Ensembl ID | ENSG00000176692 |
| Bio databases IDs | |
| Aliases | forkhead box C2, mesenchyme forkhead 1 |
| Synonyms | Fkh14, FKHL14, forkhead box C2, Hfhbf3, LD, MFH-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the FOXC2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- metastasis
- lymphedema distichiasis
- obesity
- idiopathic hydrops fetalis
- breast carcinoma
- clear cell sarcoma of the kidney
role in cell
- expression in
- formation
- quantity
- proliferation
- activation in
- phosphorylation in
- growth
- migration
- transmembrane potential
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular cardiac muscle tissue morphogenesis
- insulin receptor signaling pathway
- mesoderm development
- anatomical structure morphogenesis
- apoptotic process involved in outflow tract morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- ossification
- positive regulation of transcription, DNA-dependent
- patterning of blood vessels
- camera-type eye development
- paraxial mesodermal cell fate commitment
- glomerular mesangial cell development
- lymphangiogenesis
- positive regulation of cell adhesion mediated by integrin
- positive regulation of endothelial cell migration
- positive regulation of vascular wound healing
- neural crest cell development
- artery morphogenesis
- regulation of organ growth
- embryonic heart tube development
- response to hormone stimulus
- cardiac muscle cell proliferation
- embryonic viscerocranium morphogenesis
- regulation of transcription from RNA polymerase II promoter
- glomerular endothelium development
- vascular endothelial growth factor receptor signaling pathway
- blood vessel remodeling
- Notch signaling pathway
- metanephros development
- somitogenesis
- ureteric bud development
- glomerular visceral epithelial cell differentiation
- cell differentiation
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity