DACH1 Gene Summary [Human]
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | DACH1 |
| Official Name | dachshund family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2663] |
| Ensembl ID | ENSG00000276644 |
| Bio databases IDs | |
| Aliases | dachshund family transcription factor 1 |
| Synonyms | Dac, DACH, dachshund family transcription factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DACH1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- alpha helix
- SKI/SNO/DAC family
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- sterol sensing domain
- transcription factor activity
- DHD_Ski_Sno_Dac
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal clear cell adenocarcinoma
- prostate cancer
- chronic kidney disease
- dyspnea
- breast carcinoma
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- thrombosis
role in cell
- synthesis in
- growth
- migration
- proliferation
- phosphorylation in
- expression in
- production in
- apoptosis
- number
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DACH1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation involved in contact inhibition
- regulation of DNA replication involved in S phase
- development of primary female sexual characteristics
- respiratory gaseous exchange
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of fibroblast proliferation
- negative regulation of transcription by competitive promoter binding
- type B pancreatic cell proliferation
- suckling behavior
- negative regulation of cell migration
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear speck
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity