PPFIA3 Gene Summary [Human]
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPFIA3 |
| Official Name | PTPRF interacting protein alpha 3 [Source:HGNC Symbol;Acc:HGNC:9247] |
| Ensembl ID | ENSG00000177380 |
| Bio databases IDs | |
| Aliases | PTPRF interacting protein alpha 3, protein tyrosine phosphatase, receptor type, f polypeptide, alpha 3, liprin-alpha 3, liprin |
| Synonyms | 2410127E16Rik, Liprin alpha3, LPNA3, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), α 3, PTPRF interacting protein alpha 3, PTPRF interacting protein α 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPFIA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Crescentin protein
- Tropomyosin like
- PspA/IM30 family
- Yuri gagarin
- SAM domain
- SAM (Sterile alpha motif )
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Laminin Domain I
- Tropomyosin
- Mechanosensitive ion channel porin domain
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- phosphatase
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- liprin alpha homology domain
- Apolipoprotein A1/A4/E domain
- liprin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- microvesicles
- cytosol
- acrosome
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPFIA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle docking involved in exocytosis
- synapse organization
- regulation of short-term neuronal synaptic plasticity
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- acrosomal vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding