SORBS3 Gene Summary [Human]
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Processed Transcript |
| Official Symbol | SORBS3 |
| Official Name | sorbin and SH3 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:30907] |
| Ensembl ID | ENSG00000120896 |
| Bio databases IDs | |
| Aliases | sorbin and SH3 domain containing 3 |
| Synonyms | SCAM-1, SH3D4, SH3P3, sorbin and SH3 domain containing 3, VINE, vinexin-g, Vinexin α, Vinexin β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SORBS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- transcription factor binding
- protein binding
- vinculin binding
- fxfp sequence
- Sorbin homologous domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the SORBS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Turner syndrome
- Hutchinson-Gilford progeria syndrome
- Klinefelter syndrome
- human immunodeficiency virus I infection
role in cell
- proliferation
- formation
- migration
- size
- cell spreading
- assembly
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- intercellular junctions
- cell-cell contacts
- cytoplasmic aggregates
- cytosol
- cell-matrix adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SORBS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- cytoskeleton organization
- positive regulation of cytoskeleton organization
- positive regulation of stress fiber assembly
- cell adhesion
- positive regulation of MAPK cascade
- cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- focal adhesion
- cytoplasm
- cell-substrate junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- vinculin binding
- structural constituent of cytoskeleton