NAALADL2 Gene Summary [Human]
Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | NAALADL2 |
| Official Name | N-acetylated alpha-linked acidic dipeptidase like 2 [Source:HGNC Symbol;Acc:HGNC:23219] |
| Ensembl ID | ENSG00000177694 |
| Bio databases IDs | |
| Aliases | N-acetylated alpha-linked acidic dipeptidase like 2, glutamate carboxypeptidase II-type non-peptidase homologue |
| Synonyms | 2810043G22Rik, EG635702, Gm1021, N-acetylated alpha-linked acidic dipeptidase-like 2, N-acetylated α-linked acidic dipeptidase-like 2, RGD1565147 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAALADL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- PA
- Transferrin receptor-like dimerization domain
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- schizophrenia
- epithelial cancer
- pervasive developmental disorder
- uterine leiomyoma
- leiomyomatosis
- Kawasaki disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- COVID-19
regulated by
role in cell
- expression in
- phosphorylation in
- invasion by
- migration
- adhesion
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAALADL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
Cellular Component
Where in the cell the gene product is active
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding