SCAP Gene Summary [Human]
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | SCAP |
| Official Name | SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634] |
| Ensembl ID | ENSG00000114650 |
| Bio databases IDs | |
| Aliases | SREBF chaperone, SREBP cleavage activating protein |
| Synonyms | 9530044G19, mKIAA0199, SREBF chaperone |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholesterol binding
- binding protein
- WD40 repeats
- cytoplasmic loop
- transmembrane domain
- WD domain, G-beta repeat
- WD40
- Sterol-sensing domain of SREBP cleavage-activation
- protein binding
- steroid binding
Pathways
Biological processes and signaling networks where the SCAP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- lung cancer
- liver cancer
- hepatic injury
- coronary artery disease
- gliosis
- hepatic fibrosis
- organismal death
- hepatic steatosis
role in cell
- proliferation
- autophagy in
- quantity
- migration
- expression in
- growth
- accumulation in
- cell viability
- production in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol metabolic process
- cellular lipid metabolic process
- cargo loading into COPII-coated vesicle
- positive regulation of cholesterol biosynthetic process
- regulation of fatty acid biosynthetic process
- SREBP-mediated signaling pathway
- immune response
- response to insulin stimulus
- response to hypoxia
- regulation of cholesterol biosynthetic process
- negative regulation of cholesterol biosynthetic process
- response to vitamin B3
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- SREBP-SCAP complex
- ER to Golgi transport vesicle membrane
- membrane
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- sterol binding
- protein binding
- unfolded protein binding