ZBTB7A Gene Summary [Human]
Enables several functions, including SMAD binding activity; androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB7A |
| Official Name | zinc finger and BTB domain containing 7A [Source:HGNC Symbol;Acc:HGNC:18078] |
| Ensembl ID | ENSG00000178951 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 7A, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein, lymphoma related factor, POK erythroid myeloid ontogenic factor |
| Synonyms | 9030619K07RIK, 9130006G12Rik, FBI-1, LRF, MNDLFH, OCZF, Pokemon, TIP21, ZBTB7, zinc finger and BTB domain containing 7A, ZNF857A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB7A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger DNA binding domain
- SMAD binding
- transcription regulator
- nucleic acid binding
- BTB_POZ
- nuclear localization sequence
- androgen receptor binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
- transcription factor activity
- histone acetyltransferase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- neoplasia
- hereditary disorder
- tumorigenesis
- organismal death
- breast cancer
- prostate cancer
- seborrheic dermatitis
- inflammatory disorder
role in cell
- expression in
- apoptosis
- proliferation
- quantity
- transactivation in
- growth
- activation in
- invasion
- differentiation
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB7A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- transcription, DNA-dependent
- regulation of apoptotic process
- regulation of glycolysis
- fat cell differentiation
- negative regulation of Notch signaling pathway
- chromatin organization
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of androgen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- regulation of sequence-specific DNA binding transcription factor activity
- erythrocyte maturation
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of transcription regulatory region DNA binding
- protein localization to nucleus
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-dependent protein kinase complex
- site of double-strand break
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- histone acetyltransferase binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- SMAD binding
- androgen receptor binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity