SNX18 Gene Summary [Human]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SNX18 |
| Official Name | sorting nexin 18 [Source:HGNC Symbol;Acc:HGNC:19245] |
| Ensembl ID | ENSG00000178996 |
| Bio databases IDs | |
| Aliases | sorting nexin 18 |
| Synonyms | LOC105378967, SH3PX2, SH3PXD3B, SNAG1, sorting nexin 18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-4,5-bisphosphate binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- BAR domain
- Bin/Amphiphysin/Rvs domain
- phosphatidylinositol binding
- PX domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic face of plasma membrane
- endosomal membrane
- growth cone
- cytoplasmic vesicles
- perikaryon
- exosomes
- clathrin-coated vesicles
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cleavage furrow formation
- membrane tubulation
- cytokinesis after mitosis
- protein transport
- endosomal transport
- positive regulation of autophagic vacuole assembly
- endocytosis
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasmic vesicle
- recycling endosome membrane
- clathrin-coated vesicle
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol binding