SIRT6 Gene Summary [Human]
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SIRT6 |
| Official Name | sirtuin 6 [Source:HGNC Symbol;Acc:HGNC:14934] |
| Ensembl ID | ENSG00000077463 |
| Bio databases IDs | |
| Aliases | sirtuin 6 |
| Synonyms | 2810449N18Rik, AI043036, hSIRT6, mSIRT6, SIR2L6, sirtuin 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- NAD ADP-ribosyltransferase
- transcription co-repressor
- chromatin binding
- enzyme
- enzyme regulator activity
- protein binding
- NAD-dependent histone deacetylase activity (H3-K9 specific)
- DNA binding
- RNA binding
- protein deacetylase activity
- NAD or NADH binding
- NAD-dependent histone deacetylase
- binding protein
- damaged DNA binding
- zinc ion binding
- pentosyltransferase
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
- protein homodimerization
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the SIRT6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic inflammation
- neoplasia
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- fibrosis
- liver cancer
- cardiac hypertrophy
- organismal death
- surgically induced osteoarthritis
role in cell
- activation in
- migration
- expression in
- upregulation in
- apoptosis
- production in
- accumulation in
- phosphorylation in
- proliferation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Endoplasmic Reticulum
- nucleoplasm
- centromeres
- telomeres
- chromatin
- heterochromatin fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- negative regulation of cell proliferation
- determination of adult lifespan
- negative regulation of glycolysis
- positive regulation of fat cell differentiation
- negative regulation of gluconeogenesis
- response to UV
- regulation of circadian rhythm
- post-translational protein modification
- double-strand break repair
- positive regulation of stem cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- regulation of lipid catabolic process
- circadian regulation of gene expression
- ketone biosynthetic process
- chromatin remodeling
- positive regulation of fibroblast proliferation
- positive regulation of insulin secretion
- positive regulation of telomere maintenance
- cardiac muscle cell differentiation
- negative regulation of cellular senescence
- negative regulation of gene expression, epigenetic
- positive regulation of protein export from nucleus
- negative regulation of protein import into nucleus
- negative regulation of transcription elongation from RNA polymerase II promoter
- regulation of protein secretion
- negative regulation of glucose import
- protein deacetylation
- protein destabilization
- protein delipidation
- telomeric heterochromatin assembly
- negative regulation of transposition, RNA-mediated
- positive regulation of stem cell proliferation
- centromeric heterochromatin assembly
- glucose homeostasis
- regulation of double-strand break repair via homologous recombination
- regulation of lipid metabolic process
- positive regulation of double-strand break repair
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- nucleolus
- chromatin
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- nucleotidyltransferase activity
- zinc ion binding
- NAD-dependent histone deacetylase activity (H3-K9 specific)
- protein homodimerization activity
- nucleosome binding
- chromatin binding
- damaged DNA binding
- NAD+ ADP-ribosyltransferase activity
- NAD-dependent protein deacetylase activity
- protein binding
- transcription corepressor activity
- NAD-dependent histone deacetylase activity
- NAD+ binding