FCER1A Gene Summary [Human]
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | FCER1A |
| Official Name | Fc fragment of IgE receptor Ia [Source:HGNC Symbol;Acc:HGNC:3609] |
| Ensembl ID | ENSG00000179639 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgE receptor Ia, Fc epsilon receptor Ia, FcepsilonRI alpha chain |
| Synonyms | FCE1A, Fc epsilon R1, Fc Epsilon R1 Alpha, Fc epsilon receptor Ia, FC epsilon RI, FcERI, FCERIA, Fcr-5, Fc receptor, IgE, high affinity I, alpha polypeptide, Fc receptor, IgE, high affinity I, α polypeptide, Fc ε R1, FC ε R1 α, Fc ε receptor Ia, FC ε RI, Ig epsilon RI, Iger01, Ig ε RI, RATIGER01 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCER1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- high affinity IgE receptor
- Immunoglobulin I-set domain
- protein binding
- IgE receptor
- transmembrane receptor
- T-cell surface glycoprotein CD3 delta chain
- IgE binding
Pathways
Biological processes and signaling networks where the FCER1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- asthma
- cerebral malaria
- sepsis
- colitis
- systemic autoimmune syndrome
- diabetic nephropathy
- thrombolysis
- hypersensitivity reaction type I
- hypersensitive reaction
role in cell
- proliferation
- phosphorylation in
- survival
- apoptosis
- activation in
- expression in
- production in
- number
- degranulation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCER1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- type 2 immune response
- eosinophil degranulation
- immunoglobulin mediated immune response
- Fc-epsilon receptor signaling pathway
- cell surface receptor signaling pathway
- type I hypersensitivity
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgE binding
- high affinity IgE receptor activity