TNFSF9 Gene Summary [Human]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFSF9 |
| Official Name | TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] |
| Ensembl ID | ENSG00000125657 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 9, receptor 4-1BB ligand, homolog of mouse 4-1BB-L, CD137 ligand |
| Synonyms | 4-1BB-L, 4-IBB-L, CD137L, Ly63l, TNF superfamily member 9, TNLG5A, tumor necrosis factor (ligand) superfamily, member 9, tumour necrosis factor (ligand) superfamily, member 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFSF9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- cytoplasmic domain
- TNF
- intracellular domain
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the TNFSF9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- systemic lupus erythematosus
- tumor
- adenoma formation
- benign neoplasia
- Marfan syndrome
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- lymphomagenesis
role in cell
- proliferation
- cell death
- apoptosis
- production in
- expression in
- differentiation
- activation in
- glycolysis in
- survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFSF9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- immune response
- positive regulation of cytotoxic T cell differentiation
- signal transduction
- cell-cell signaling
- regulation of apoptotic process
- positive regulation of activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor superfamily binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding